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This observation suggests that each serine doublet might play a specialised function in the phosphorylation process, for example by recruiting specific GRKs, as shown in the present study for GRK2, which requires the presence of the third serine doublet at position 451/452 of the C-terminal tail to be recruited to the receptor downstream of GLP-1 stimulation

This clustering of disorders is often due to shared genetic susceptibility, allowing multiple autoimmune diseases to arise in a single individual

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Roughly one in five prescriptions written in the US is off-label

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