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Caspase activation assay Caspase activation was assessed using the Caspase-Glo 3/7 agent (Promega, Madison, USA) for GSTP-silenced PANC-1 cells

Immune cells are particularly sensitive to oxidative stress because of their high percentage of polyunsaturated fatty acids in the plasma membranes, along with naturally producing more oxidative products

First, p53 mutations contribute to the complexity and evolution of tumors through several mechanisms, enhancing tumor heterogeneity, invasiveness, and treatment resistance

Based on Phase 2 clinical trial protocols conducted by Eli Lilly, initiation was typically at 2 mg administered once weekly via subcutaneous injection

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