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In conclusion, MNs/GLP-1RAs@NPs-WYRGRL could increase the expression of GLP-1R, inhibit the cGAS-STING signaling pathway, suppress ferroptosis in chondrocytes of articular cartilage, and promote the expression of chondrocyte-related mechanisms such as ACAN and COL2
These agents work well alongside osmotic laxatives and pose minimal risk of habituation
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