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thus, studies are proposed to have a duration of 6 months to allow the detection of clinically meaningful changes in bone structure (by DXA or other imaging modalities) (Reference Zibellini, Seimon and Lee7)

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The 5mg quantity allows researchers to validate their experimental approach and confirm compatibility with their assay system before committing to larger quantities

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Thus, the use of this approach allowed to identify an original target, the protein kinase DYRK1B, suggesting that an inhibitor of this protein could present a possible senolytic activity 40