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The Nrf2/Keap1/ARE pathway, along with other signaling pathways such as Sirt1/p66Shc and NLRP3/caspase-1/GSDMD, are involved in mediating oxidative stress and inflammation in doxorubicin-induced cardiomyopathy [69]

MSM and magnesium bisglycinate are also essential for glutathione metabolism, as well as selenium and vitamin B (B2, B6 and B9)

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Small molecules such as RSL3 and erastin, which primarily target GPX4 and SLC7A11, respectively, demonstrate that impairment of cystine uptake or lipid peroxide detoxification is sufficient to directly trigger ferroptotic cell death

These formulations help accelerate cell turnover whilst brightening existing pigmentation