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According to recent studies, vegetarian and vegan diets can be successfully used in FM management [22], as plant-based diets have a positive anti-inflammatory effect on gut microbiome and, in general, help resist systemic inflammation [23]

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These autoantibodies induce inflammation, vasoconstriction, and remodeling by directly binding to vascular cell targets, and activate the complement cascade and IgE-mast cell axis, amplifying pulmonary vascular inflammation and remodeling (Heukels et al., 2021

Moreover the hormonal rearrangement intrinsic of pregnancy [17] redistributes the interrelationships of metabolic pathways that sustain fetus growth and differentiation, particularly in rats, that have a short pregnancy (about 17 d)