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Dermal fibroblasts progressively differentiate toward a myofibroblast phenotype [87], characterized by increased expression of contractile and ECM-associated genes such as ACTA2 and COL1A1 [88], that promote early sinus tracts formation and collagen accumulation

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Additionally, a double-blind clinical trial reported that continuous intake of a PCs-rich beverage, largely composed of catechin, stimulated insulin secretion and enhanced blood glucose control in individuals with type 2 diabetes (Tomonori et al., 2009)