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In addition, crocetin administration reduces follicle loss and rescues fertility in CPM-treated mice

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For instance, the nitric oxide reductase NorB and the cytochrome c (CycP) detoxified NO produced by macrophages (Stevanin et al., 2005), while PorB-TLR2 interaction enhances anti-inflammatory IL-10 production (Samarasinghe et al., 2006) and modulates Nf-B signaling (Oliveira-Nascimento et al., 2012), reprogramming dendritic cells toward a Th2 response (Mukherjee et al., 2016)