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Men have reported that headaches experienced from popular erectile dysfunction medications like Viagra and Cialis were more intense and lasted longer than those experienced with PT-141

Okano N, Naruge D, Kawai K, Kobayashi T, Nagashima F, Endou H, et al

Stimulatory signals: GHRH from hypothalamus (primary stimulator), ghrelin from stomach, deep sleep, exercise, fasting/low blood glucose, certain amino acids

Other effects remain minimal during this early phase as growth hormone levels gradually increase