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HMT is present in the cytosol of cells in many tissues including the kidneys, liver, spleen, prostate, ovaries, spinal cord, bronchi, and trachea.[4] HMT is present in the airway tissues which play an important role in degrading histamine and regulating the airway response to histamine.[5] The intermediate products of histamine metabolism via HMT are broken down by the enzymes monoamine oxidase B (MAO B) and aldehyde dehydrogenase (ALDH).1,[6] HMT catalyzes the methylation of histamine in the presence of methyl donors such as S-adenosyl-L-methionine (SAMe).[7] Single nucleotide polymorphisms (SNPs) in any of these enzymes may affect the bodys ability to metabolise and eliminate histamine and the products of its catabolism.[8] Diamine oxidase (DAO), also known as histaminase, is the main enzyme responsible for the metabolism of ingested histamine

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