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2, the NADPH homeostasis is mainly regulated by several metabolic pathways and enzymes including NAD kinase (NADK), the pentose phosphate pathway (PPP), the folate-mediated one-carbon metabolism, malic enzymes (ME), the nicotinamide nucleotide transhydrogenase (NNT), cytosolic or mitochondrial NADP-dependent isocitrate dehydrogenase (IDH1 and IDH2), the glutamine metabolism, and the fatty acid oxidation (FAO)

Growth hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth hormone deficiency

Patients typically see meaningful, sustained body weight reduction over 6 to 12 months when the program is followed consistently

Persistent vomiting or regurgitation of undigested food

How do genetic factors influence injection tolerance and pain sensitivity