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Zaben M et al (2021) IL-1beta and HMGB1 are anti-neurogenic to endogenous neural stem cells in the sclerotic epileptic human hippocampus

The ensuing pathology, largely consisting of macrophage and lymphocyte infiltration of mainly the spinal cord, recapitulates the inflammatory pathology of acute MS lesions in a number of respects, but differs from MS in important ways: many EAE variants exhibit only limited demyelination confined to the spinal cord white matter, contrasting with extensive brain pathology also prominently affecting cortical gray matter in MS

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Within 8 weeks, his knee pain reduced by 70%, allowing him to return to full duty workouts