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The reasons for a vitamin B12 deficiency are manifold: Unfavourable eating habits (for example fast food and convenience food), absorption disorders in older age, a strict vegetarian diet or certain intestinal diseases are frequent causes
We hence establish a crucial role of GIPR signalling in peripheral neurons in the regulation of glucose homeostasis, but not body weight, under conditions of diet-induced obesity
Together, these peptides provide a framework for studying how multiple signaling pathways may interact within controlled systems
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