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Conclusion Whilst severe B12 deficiency has a clear clinical picture with characteristic haematological and/or neurological features, establishing mild or borderline deficiency can be problematic as serum levels are maintained at the expense of tissue concentrations, and therefore serum levels of B12 may be in the low normal or borderline range despite a deficiency

It is metabolized by the liver and it participates in various metabolic processes like synthesis and degradation of amino acids

Oral supplementation is appropriate for patients with dietary insufficiency and intact absorption mechanisms

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Or that the symptoms of vitamin B12 deficiency can closely mimic hypothyroidism