It is commonly used in models involving lipid-metabolism models, fat-related signaling pathways, and growth-hormone-fragment structure activity research
Importantly, this model is consistent with requirements for both Aldh1a1 and GAT for robust striatal DA/GABA IPSCs (Tritsch et al., 2014
Detection of percentage positive cells was based on a threshold, typically set according to the average pixel intensity of an internal negative control or an unstained secondary antibody-only control sample, unless specified
The major advantage of this approach is that small molecules have a considerable higher bioavailability compared to antibodies, dominant-negative receptors and antisense oligonucleotides
Wimberley T, Brikell I, Astrup A, Larsen JT, Petersen LV, Albiana C, et al