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R: Periodic reviews Blood pressure Baseline, weeks 2, 4, 8, every 8 weeks Transitory increase of 10-15 mmHg systolic post-dose (monitor) Skin pigmentation Visual inspection, standardized photographs Sexual function Validated scales (FSFI, IIEF) monthly Adverse effects: Prospective registration events, severity Laboratory Metabolic profile, baseline liver/kidney function, and semester (optional) EXTENDED RESEARCH REFERENCES Kingsberg SA, et al

A systematic review of evidence on the use of very low calorie diets in people with diabetes

Activity levels should still match individual fitness ability and medical advice