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It engages in higher functions of the brain including spatial memory [2], motivation [3], arousal [4], reward and pleasure [5, 6], in addition to regulating motor neurons [7], lactation [8], sexual behavior [9], and nausea [10]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Benedetti F, Poletti S, Hoogenboezem TA, Locatelli C, de Wit H, Wijkhuijs AJM, Colombo C, Drexhage HA (2017) Higher baseline proinflammatory cytokines mark poor antidepressant response in bipolar disorder