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When kidney function declines, drugs and their metabolites can accumulate, increasing the risk of toxicity and adverse drug reactions

These advances could pave the way for therapies not only for rare mitochondrial disorders but also for more common conditions linked to mitochondrial dysfunction, such as heart disease and neurodegeneration

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It mitigates H 2 O 2 -induced damage, enhances SOD activity [422], and activates the antioxidant response element (ARE)-Nrf2 pathway [423], thereby protecting RPE cells against elevated ROS levels

[344] ED boarding, defined as holding a patient in the ED when there are no available inpatient beds, often occurs due to shortages of inpatient beds and staff