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Exp Mol Med 32(3):127 Wu XJ, Hu Y, Lamy E, Mersch-Sundermann V (2009) Apoptosis induction in human lung adenocarcinoma cells by oil-soluble allyl sulfides: triggers, pathways, and modulators

However, the increase in urinary sodium and water excretion after intrarenal infusion of Ang-(17) in dogs was reduced by AT 1 , but not AT 2 receptor blockade, suggesting a role for Ang-(17)-mediated signaling via the AT 1 receptor

Data showed weight loss of roughly 1.03 pounds per month per patient and no serious adverse effects despite evidence of new lesional activity in a small number of enrollees

However, therapeutic application of PXR and CAR agonists faces caveats: (1) species-specific differences in receptor activation limit direct translation from rodents to humans