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Statements Author contributions JL: Writing original draft

Wang H, Huang M, Bei W, Yang Y, Song L, Zhang D, et al

In contrast to the typical amide bond (between the -carboxyl group of one amino acid and the -amino group of another) that links virtually all of the amino acids in naturally occurring peptides and proteins (as well as the cysteine and glycine in glutathione), it is the -carboxyl group of glutamate that is bound to the nitrogen of cysteine (see Figure 1, in which this bond is highlighted by red circles)