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examined an aging human cohort with several cardiovascular risk factors and demonstrated that the changes in the platelet redox phenotype with age do not follow a linear trend but rather an inverted U-shaped curve [149]

While anchoring osteoclasts, LPS also activates the TLR4 signaling on the surface of macrophages, prompting the secretion and aggregation of cytokines such as TNF- and IL-6 (77)

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