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However, CMS has clarified that the currently used USP guidelines do not include categories and classes of drugs for anorexia, weight loss, or weight gain and these drugs are not required to be covered under EHB rules

Another consideration is the potential impact on the immune system

Br J Pharmacol 92(2):457468 Holger JS, Engebretsen KM, Stellpflug SJ, Cole JB, Cooper AC, Harris CR (2010) A consecutive case series (abstract)

For biologics, where the interchangeability barrier and PBM rebate dynamics slow substitution, the erosion is more prolonged but the trajectory is identical

CMO 17.8