The cardiac benefits of GLP-1 agonists were not anticipated before outcome studies were performed for several reasons: (1) Historical Precedent-past experiences with other diabetes medications that unexpectedly had adverse cardiovascular effects made it less likely for researchers and clinicians to anticipate potential cardiovascular benefits without concrete evidence from large-scale trials
Arutjunyan A, Kozina L, Stvolinskiy S et al (2012) Pinealon protects the rat offspring from prenatal hyperhomocysteinemia
This is why its so important to discuss your full medical history, including any known allergies, with your doctor before starting treatment
More recently, a randomised controlled trial of lixisenatide in early Parkinson's disease (the LIXIPARK study) was published in the New England Journal of Medicine (2024)
a , Body weight of Control, Bmal1 -KO, and Bmal1 -KO + NDI1 mice at 4 months of age on a chow diet (n = 7 Control, n = 6 Bmal1 -KO, and n = 5 Bmal1 -KO + NDI1)