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Beetroot is high in oxalates, which can contribute to calcium oxalate kidney stone formation in those with a history of nephrolithiasis

10.1016/j.pharep.2014.08.009 10 Bobowski-GerardM.DebaeckerS.Stankovic ValentinN.TessierA.ElkhatibH.DelatailleP.et al (2024)

Several of the clinical trials showing a skin-brightening effect included vitamin C alongside glutathione rather than testing glutathione entirely alone

Gpx4 is an essential mammalian glutathione peroxidase, which protects cells against detrimental lipid peroxidation and governs a novel form of regulated necrotic cell death, called ferroptosis