Labs typically incorporate standard safety procedures, including PPE, proper sharps handling when needles are used in animal studies, and clearly labeled storage
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287 The aggregation of mutant huntingtin protein disrupts numerous cellular processes, including transcription and translation regulation, 288,289 amino acid homeostasis, 290 antioxidant and stress responses, 291,292 DNA repair, and autophagy
2- Take notes of the dose, route of administration, and the manufacturer name (if specified by the provider)
Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies