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Native IGF-1 exists as an approved drug called mecasermin (Increlex) for severe primary IGF-1 deficiency, but mecasermin is a different molecule it is native IGF-1, not the LR3 analog

167 Another large study examined data on main lifetime occupation for 7,637 individuals 65 or older in the Chicago Health and Aging Project study and found that higher occupational cognitive requirements corresponded to significantly better latelife cognitive performance at baseline and to slower decline in global cognitive function over time

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