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Notably, quercetin and kaempferol have been shown to inhibit the expression of cyclin D1 and CDK4/6 while increasing the levels of CDK inhibitors (p21, p27), thereby blocking passage through the G1 checkpoint in osteosarcoma models and reducing clonogenic survival 44,45

doi:10.1111/jcmm.13952 70

doi: 10.1038/s41574-023-00816-5 240 Evans-MolinaCDorYLernmarkMathieuCMillmanJRMirmiraRGet al

A history of preterm birth, both with and without a history of BPD, has been consistently associated with poorer lung function in later life 4 , and there is growing evidence that those with a history of BPD risk the development of chronic obstructive pulmonary disease (COPD) in early adulthood 5, 6 , as well as being diagnosed with asthma 7 , although there is increasing recognition that prematurity-associated lung disease (PLD) has different underlying mechanism to asthma 8

doi: 10.1016/j.eclinm.2022.101737