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Retatrutide's hepatic effects extend beyond simple fat reduction

April 2025 PCWHS

System Xc-, cystine/glutamate antiporter SLC7A11 Solute Carrier Family 7 Member 11 SLC3A2 Solute Carrier Family 3 Member 2 STYK1 serine threonine tyrosine kinase 1 SEPHS2 selenophosphate synthetase 2 S1R Sigma-1 receptor SIRT6 Sirtuins 6 STAT3 Signal transducer and activator of Transcription 3 SFRS9 Serine and arginine rich splicing factor 9 TrxR1 thioredoxin reductase 1 Trit1, tRNA isopentenyltransferase 1 TGF-1 Transforming growth factor 1 USP7 Ubiquitin Specific peptidase 7 -GC -glutamylcysteine 5-FU 5-fluorouracil 8-OHG Hydroxyguanosine 8 References 1 AldersonN

Plasma Untargeted Metabolomic Studies Metabolomic studies on plasma have thus far tended to roughly corroborate the findings observed in urine, although specific differences have been proposed to be due to differences in renal clearance for some compounds