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however, VEGF, IL-1a, IL-6, IL-8, MMPs, and chemokines (CXCL2, CXCL3) are secreted by most senescent cells 10,12

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Biometals 31(5):845858

2.4.2 Neuroendocrinereproductive axis: coupling of appetitive centers and reproductive neurons The expression of receptors in hypothalamic reproductive nuclei provides a biological basis for a direct influence on the reproductive axis