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doi: 10.1007/s11892-014-0491-3

Published clinical evidence includes a Phase 1b multiple-ascending-dose trial reported by Enebo and colleagues (Lancet, 2021) and a Phase 2 trial in type 2 diabetes reported by Frias and colleagues (Lancet, 2023), both studying cagrilintide together with semaglutide

Notably, CYP27B1 is also expressed in extra-renal tissues such as the placenta and prostate, where it facilitates local synthesis of 1,25(OH)D to modulate cellular functions via paracrine or autocrine signaling [96, 99]

Curr Pain Headache Rep 28:453456

In: Nelson L, Howland M, Lewin N, Smith S, Goldfrank L, Hoffman R, eds