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GLP-1R regulation of food reward In addition to being expressed in hypothalamic areas that regulate homeostatic feeding, the GLP-1R is expressed in areas that mediate food reward in both rodents (Merchenthaler et al., 1999) and non-human primates (Heppner et al., 2015)

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In summary, natural plant polysaccharides can modulate the PI3K/AKT and NF-B signaling pathways, thereby reducing the release of inflammatory factors and decreasing the downstream expression levels of inflammation-related proteins