Recent large-scale observational and meta-analytic studies have compared the cognitive effects of different antidiabetic therapies, generally reporting stronger associations between GLP-1 RAs or SGLT-2 inhibitors and reduced dementia risk compared with metformin
For example, researchers behind one small randomized controlled trial found that participants with obesity who ate half a fresh grapefruit before each meal for 12 weeks lost an average of 1.6 kilograms (kg), or about 3.5 pounds (lb), compared with a control group who lost 0.3 kg, which is less than 1 lb
Using computer simulations, researchers from TU/es Computational Biology group have now provided insight into how these miracle drugs lead to successful weight loss
Int J Clin Exp Med 5:179185 Asaba T, Hamano S, Nanmo A et al (2025) Human iPSC-derived cerebral organoids reveal oxytocin-mediated protection against amyloid- pathology
However, after morphogenesis, rather than entering a new hair cycle like the WT, the hair shafts of Het mice were shed (Figure 5figure supplement 1A,B)
