Alpha-lipoic acid has been most extensively studied for diabetic peripheral neuropathy, where it has been approved as a prescription treatment in Germany since the 1960s [2]
PubMed Central, Cai, Miao, et al
Studies in metabolic disease consistently report elevated systemic LPS levels associated with dysbiosis and metabolic endotoxemia (Dong et al., 2022), and these increases correlate with -cell transcriptional stress signatures observed in scRNA-seq analyses, including the expansion of ATF4 + and XBP1 + subclusters and the downregulation of maturity-related transcription factors such as PDX1 and MAFA under inflammatory conditions (Sokolowski et al., 2024)
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The observed decrease in cell inhibition rate following the introduction of a receptor blocker provides additional support for its targeting mechanism, which is specifically designed to interact with GR and MR that are abundantly expressed on the surface of liver cancer cells
