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GLP-1 receptor agonists begin working at a physiological level shortly after administration , but the clinical effects patients notice develop more gradually over days to weeks

In a poor nutritional state, GSH reserves become easily exhausted and hepatic glucouronidation is stunted, leading to decreased levels of available GSH that would otherwise be scavenged for formation of reactive metabolites in phase I of APAP metabolism

Diarrhea : Frequent, watery bowel movements that can result in dehydration and electrolyte imbalance

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Treatment with RSL3 (a ferroptosis inducer) has been found to downregulate SLC2A3 expression and induce ferroptosis in RA fibroblast-like synoviocytes (RA-FLS) [163]