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Rather than viewing complexity as an inherent liability, contemporary pharmacology increasingly recognizes that pleiotropic signaling can be therapeutically advantageous when appropriately modulated through dosing, bias, and patient stratification (Kenakin, 2019

While peroxidases were known at the time, and their possible involvement in ascorbate oxidation previously noted (Mapson and Goddard 1951), the physiological functions of such enzymes were considered to be as much in H 2 O 2 -dependent oxidations as reductant-dependent H 2 O 2 removal