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The main drawbacks involve needle discomfort, potential injection site reactions, and the requirement for sterile technique

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A 2024 randomized controlled trial (RCT) with 60 women (ages 40-65) applied 0.1% GHK-Cu cream twice daily for 12 weeks, yielding 31% wrinkle reduction (visia analysis) and 28% improved skin elasticity versus placebo (Kim et al., 2024)

Tissue that was clearly damaged may demonstrate functional recovery

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