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In addition, the delivered cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) siRNA (NPsiCTLA-4) can deliver CTLA-4 siRNA to CD4 (+) and CD8 (+) T cell subsets at the tumor site, significantly increasing CD8 (+) T cells and reducing the proportion of Tregs, while also enhancing the activation of tumor-infiltrating T cells and antitumor immune responses (173)

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Yang S, Shen W, Zhang HZ, Wang CX, Yu WQ, Wu QH

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Therapeutic role of Annona muricata fruit and bee venom against MNU-induced breast cancer in pregnant rats and its complications on the ovaries