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Currently, the effects of 2.4 mg semaglutide once weekly are being explored in 1200 participants with biopsy-confirmed NASH in a Phase III clinical trial with a combined primary endpoint of resolution of NASH without worsening fibrosis, improvement in liver fibrosis without worsening of steatohepatitis, and time to first liver-related clinical event (NCT04822181) (see Table 2)

However, long-term data remains limited

The SURMOUNT-5 trial reported the following adverse events: Common Side Effects Most gastrointestinal side effects are mild to moderate and tend to occur during the dose escalation phase