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This includes individuals with a personal or family history of medullary thyroid carcinoma, those with Multiple Endocrine Neoplasia syndrome type 2, patients with type 1 diabetes or diabetic ketoacidosis, anyone currently taking another GLP-1 receptor agonist medication, pregnant or breastfeeding individuals, and patients with active pancreatitis

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The Joint Expert Committee on Food Additives (JECFA) has defined an acceptable daily intake (ADI) of 0.152.0 mg/kg body weight per day for -tocopherol [89]