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This rapid improvement can be attributed to MPFFs multifaceted pharmacological action, which includes reduction of capillary hyperpermeability, inhibition of inflammatory mediators (e.g., prostaglandins and free radicals), and enhancement of venous tone

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Vitamin B12 Deficiency Causes of vitamin B12 deficiency include difficulty absorbing vitamin B12 from food, lack of intrinsic factor (e.g., because of pernicious anemia), surgery in the gastrointestinal tract, prolonged use of certain medications (e.g., metformin or proton pump inhibitors), and dietary deficiency