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Lipid peroxide accumulation is inhibited by glutathione peroxidase 4 (GPX4), a lipid hydroperoxidase that uses reduced GSH as a cofactor (Friedmann Angeli et al, 2014

By day five, the morning hobble was noticeably less severe

To correct for this, we performed RNA-seq analysis of hypothalami obtained from animals treated with daily injections of either GLP-1MK-801 or a dose of semaglutide that was equipotent in terms of weight-lowering efficacy over 5 days of treatment, that is, mice had achieved a comparable weight loss and reduction in food intake as that of GLP-1MK-801-treated mice (Extended Data Fig

This test can help guide treatment when indicated

In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG