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Because the benefits of intensive glucose control emerge slowly while the harms can be immediate, people with longer life expectancy have more to gain from early intensive glycaemic management

These medicines should not be prescribed without intensive lifestyle changes, notes Dr

Overall prescribing rates (GLP-1 RA prescriptions per total prescriptions) in September 2025 remained stable relative to June 2025 (+4.6%)

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In people who struggle with weight, these signals can be weaker than they should be the body may not produce enough GLP-1, or the brain may not respond to it with the same sensitivity