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5-Amino-1MQ is a small-molecule competitive inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the methylation of nicotinamide using S-adenosyl methionine (SAM)

NO activates guanylate cyclase and elevates cyclic Guanosine Monophosphate (cGMP)

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Human chondrocytes in vitro (Huang/Zhu et al., 2021) Selectively removed senescent cells from expanded human chondrocyte cultures, suggesting cartilage-repair relevance in a dish, not a person