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For medications that are used off-label we can only provide guidelines and safety information for use

It is currently under clinical investigation for the management of obesity and type 2 diabetes (as demonstrated in a phase 2 trial published in the New England Journal of Medicine), and as of the time of writing, it has not received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA)

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The combination is particularly relevant for patients losing 20%+ of body weight, where muscle preservation becomes a critical concern

maybe they lose about 50 pounds