If the nuclear accumulation of G and arrestin3 is essential for D 3 R desensitization, desensitization should cease upon interruption of nuclear accumulation
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A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
Additionally, more than one receptor type and different G-protein coupling of neuropeptide receptors in different tissues lead to variable effects of the same neuropeptides in different tissues/cell types [24,25,26,27,28,29,30,31,32,33,34,35,36]
"Choosing" between them is therefore a matter of which research domain is of interest, not a clinical decision with established outcomes