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The later activation was found to increase transcription of cortical and hippocampal BDNF and send molecular signals necessary for maintaining neuronal survival

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In addition, the reduced total glutathione content and lower ratio of GSH:GSSG were analysed and interpreted as evidence of redox imbalance and has been associated with various human disease, including PD 42,43

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Control or methylene blue pretreated rabbit pulmonary arterial smooth muscle were stimulated with sodium nitroprusside, nitrosothiols or endothelium derived relaxing factor released basally from bovine pulmonary arterial endothelial cells, in short term cocultures