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At a base level things like alcohol and tobacco or a meat rich diet can increase oxidative stress

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In addition, a recently characterized GST from Leishmania infantum (TDR1 protein) does not exhibit the canonical dimerization mode but consists of a unique trimer of subunits each containing two glutathione S-transferase domains (Figure S1C) (Fyfe et al., 2012)

Whereas restless leg syndrome is associated with both an iron deficiency in the brain for genetically susceptible individuals and dopaminergic system dysfunction, potentially involving a presynaptic hyperdopaminergic state, in other patient populations

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