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The glucose-dependence that makes them safe, the central action that drives weight loss, the cardiovascular and renal benefits, and the gastrointestinal side effects all trace back to where the receptor sits and how it signals

In a double-blind study by Bailey et al., 2015 Journal of Applied Physiology , subjects supplementing with citrulline demonstrated improved exercise tolerance and reduced perception of fatigue during high-intensity cycling

C., Molero-Labarta, T., Domnguez-Cabrera, C., Hortal-Cascn, L., Prez-Borges, P., et al

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The study did not include people who paid cash to fill their prescriptions