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The prolonged duration of withdrawal symptoms and the enduring distress experienced by individuals undergoing drug withdrawal [3,4,70] contribute to the complexity of relapse causation [3,7173]

Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

Furthermore, studies have suggested that these drugs may also potentially reduce the risk of heart disease, making them beneficial for cardiovascular health

Oxidised glutathione (GSSG) is the spent form that must be recycled back

Therefore, the reduced capacity to carry out the methionine synthase reaction, due to nutritional or disease mediated deficiency of vitamin B12, results in reduced SAM production and as a consequence contributes to the neural degeneration (i.e