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In contrast to other GPxs, GPx4 is the only one that reduces the hydroperoxides of lipoproteins and complex lipids, such as cholesterol, cholesterol esters, and phospholipids [108], to protect mitochondrial ATP generation from oxidative damage [109]

At a glance, the table underscores the throughline of this entire comparison: none of these three compounds substitutes for another, because each is anchored to a different level of biological activity cellular, mitochondrial, and endocrine, respectively

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The invisible problem Here is what makes this tricky

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